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Inhibition of the hSULT1E1-catalyzed sulfation of 7.0 nM estradiol by major metabolites of tamoxifen. Rates of sulfation of estradiol for uninhibited controls were 62, 67, 58, and 69 nmol/min/mg protein for studies with endoxifen, N-desTAM, 4-OHTAM, and TAM-NO, respectively. Data are the means ± S.E. from triplicate determinations.
