TABLE 2.
Plasma and tissue AUC values and ratios for healthy and CIA rats
| Tissue | AUC0–264 h | Tissue/Plasma AUC Ratio | ||
|---|---|---|---|---|
| Healthy (SD)a | CIA (SD)a | Healthy | CIA | |
| μg/ml • h | ||||
| Lung | 285.6 (39.0) | 248.3 (52.2) | 0.1290 | 0.1490 |
| Liver | 110.1 (32.4) | 135.7 (29.5) | 0.0487 | 0.0939 |
| Kidneyb | 177.1 (19.5) | 334.7 (55.2) | 0.0783 | 0.2320 |
| Spleen | 172.4 (35.8) | 121.2 (20.1) | 0.0762 | 0.0838 |
| Heart | 207.1 (34.4) | 111.4 (19.7) | 0.0916 | 0.0771 |
| Muscle | 80.9 (12.7) | 88.3 (24.8) | 0.0358 | 0.0611 |
| Adipose | 88.5 (20.3) | 87.9 (34.7) | 0.0391 | 0.0608 |
| Paw | 148.6 (21.8) | 338.6 (82.9) | 0.0657 | 0.2340 |
| Blister fluid | 970.2 (293.7) | 1006.6 (412.3) | 0.4290 | 0.6960 |
| Plasma | 2260.9 (213.6) | 1445.2 (370.6) | ||
a
SD of AUC0–264 h was calculated using NCA with sparse sampling using WinNonlin 6.1 (Nedelman and Jia, 1998; Holder, 2001).
b
Concentrations of etanercept in kidney used for calculation of AUC are subject to poor data quality.