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. 2014 Jul 29;22(11):1910–1922. doi: 10.1038/mt.2014.117

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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PK and biodistribution of PSMA aptamer, A9g. (a) Near NIR labeled aptamers NIR-A9g and NIRA9g.6 were injected tail vein in mice bearing PSMA⁺ tumors (implanted subcutaneously) and tracked over time with the IVIS 200 imaging system (PerkinElmer). Ex-vivo: tumors were excised at day 4 (96 hours) post-injection. (b) PK and biodistribution of NIR-A9g in a control, non-tumor-bearing mouse. (c) Specific targeting of PSMA positive tumor by A9g. NIR-A9g (top row) or NIR-A9g.6 (bottom row) were injected tail vein in SCID mice bearing subcutaneous PSMA⁺ (right flank) or PSMA⁻ (left flank) prostate cancer tumors. Images were acquired with the IVIS 200 imaging system (PerkinElmer) at the indicated time points following injection of the labeled RNAs.