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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Apr 19;262(1):11–21. doi: 10.1016/j.taap.2012.04.014

Figure 6.

Figure 6

Carcinogenic metals increased the expression of β-catenin and phospho-GSK3β in CRL-1807 cells in does- and time- dependent manner. CRL-1807 cells were treated with Cr(VI) (0, 1, 2, 4 µM), As(III) (0, 1, 5, 10 µM), or their combination for 24 h, or treated with 4 µM Cr(VI), 10 µM As(III), or 2 µM of As(III) combination with 2 µM of Cr(VI) for indicated time points. The expression of β-catenin and phospho-GSK3β were determined with immunoblotting. The expression of actin served as an internal control. As2+Cr1, As2+Cr2, As2+Cr4: 2 µM of As(III) combination with 1, 2, 4 µM of Cr(VI), respectively.