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Over-expression of CD137L on tumor cells enhances anti-tumor effects of CRT. Tumor growth curves (for individual mice) and group Kaplan-Meier survival curves are shown for mice implanted with (A) parental mEERLs, (B) mEERLs over-expressing CD137L (OE), or (C) mEERLs minimally expressing CD137L (ME). Mice received three doses of cisplatin (20 mg/kg) and radiation (8 Gy) on indicated days (arrows), (D) Kaplan-Meier survival curves for mice in A, B and C.
