Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 28;6:368. doi: 10.3389/fmicb.2015.00368

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Shahinas, Debnath, Benedict, McKerrow and Pillai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Illustration of ATP binding pocket differences. (A) Molecular model of adenosine diphosphate (ADP) in the adenosine triphosphate (ATP) binding pocket of human (2FWZ) Hsp90 (HsHsp90). (B) Molecular model of ADP in the ATP binding pocket of P. falciparum (3K60) Hsp90 (PfHsp90). (C) Molecular model of ADP in the ATP binding pocket of E. histolytica Hsp90 (EhHsp90) (based on PfHsp90 template: 3K60). (D) Summary of the unique residues in the ATP binding pockets of HsHsp90, PfHsp90 and EhHsp90. Please note that these residues are at conserved positions in the 3D model. These residues were mutated by site-directed mutagenesis to examine alterations in binding specificity.