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. 2015 May 8;12:86. doi: 10.1186/s12974-015-0308-6

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© Cipriani et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histological analysis of the protective effect of FTY720 in CA3 region following icv injection of kainic acid (KA). Slices collected 3 days after icv surgery were stained with Nissl (A, B), Fluoro-Jade C (FJC) (C), and anti-NeuN antibody (D). Figure shows representative photomicrographs of bright field (A, B, D) and epifluorescence (C) microscopy images obtained from coronal sections of KA-treated (left panel) and KA + FTY720-treated animal groups (right panel). Only the damaged ipsilateral hemisphere is shown. KA-induced cell death is evident in the CA3 region, as indicated by Nissl’s staining (A, B), lower number of NeuN⁺ cells (D), and increased density of FJC⁺ neurons (C). KA + FTY720-treated group (right panel) shows significant attenuated loss of neurons as compared to KA-treated group (left panel). (A) Dorsal ipsilateral hippocampus. Scale bar: 1 mm. (B-D) CA3 region of ipsilateral hippocampus. Scale bar 500 μm.