Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Leg cramp symptoms
Systematic review	People with cramps 2 RCTs in this analysis	Percentage change in cramp frequency from baseline to 4 weeks with magnesium with placebo	Mean difference –3.93 95% CI –21.12 to +13.26 P = 0.65		Not significant
Systematic review	People with cramps 2 RCTs in this analysis	Proportion of people with at least 25% reduction in cramp frequency 4 weeks 24/42 (57%) with magnesium 27/41 (66%) with placebo	Risk difference –0.08 95% CI –0.28 to +0.12 P = 0.44		Not significant
Systematic review	People with cramps 4 RCTs in this analysis	Number of cramps per week 4 weeks with magnesium with placebo	Mean difference +0.01 95% CI –0.52 to +0.55 P = 0.96		Not significant
Systematic review	People with cramps 3 RCTs in this analysis	Cramp intensity (pain) on a 3-point scale (1 = mild; 2 = moderate; 3 = severe) 4 weeks with magnesium with placebo	Mean difference –0.04 95% CI –0.18 to +0.11 P = 0.62		Not significant