Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Leg cramp symptoms
RCT	42 pregnant women In review	Women with persisting leg cramps 2/21 (10%) with calcium 18/21 (86%) with no treatment	OR 0.05 95% CI 0.02 to 0.17 See Comment for details of methodological limitations	Large effect size	calcium
RCT	60 pregnant women In review	Women with persisting leg cramps 11/30 (37%) with calcium 8/30 (27%) with vitamin C placebo	OR 1.58 95% CI 0.54 to 4.63 See Comment for details of methodological limitations		Not significant