Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Leg cramp symptoms
Systematic review	13 people experiencing 2 or more leg cramps per week	Number of cramps 2-week treatment phase with diltiazem hydrochloride with placebo Absolute results not reported	P = 0.04 Caution should be taken in interpreting this result (see Comment)	Effect size not calculated	diltiazem
Systematic review	13 people experiencing 2 or more leg cramps per week	Intensity of leg cramps (1–3 point scale, measure of intensity not further defined) with diltiazem hydrochloride with placebo Absolute results not reported	P = 0.347 Caution should be taken in interpreting this result (see Comment)		Not significant