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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: J Pediatr Hematol Oncol. 2015 Mar;37(2):79–93. doi: 10.1097/MPH.0000000000000303

Figure 2.

Figure 2

NK cell surface receptors and their ligands. Receptors are broadly classified based on their primary function (inhibitory receptors, activating receptors, and activating co-receptors). Known ligands are denoted in parentheses. Despite the multitude of receptors shown, other families of receptors are not illustrated, including cytokine receptors (e.g., IL-1, IL-2, IL-12, IL-15, IL-18, IL-21, IFNα), chemotactic receptors (CCR2, CCR5, CXCR1, CXCR3, CXCR4, CXCR6, CX3CR1 and Chem23R), adhesion receptors (CD2 and β1 and β2 integrins), and inhibitory co-receptors (CD300A, LAIR-1 and Siglec7). Adapted with permission from: Wing Leung, Use of NK cell activity in cure by transplant, British Journal of Haematology 155, 14–29, 2011, Blackwell Publishing Ltd.