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Schematic representation of immunocytokine-facilitated tumor cell-NK cell conjugate formation. Tumor cells coated with immunocytokine bind NK cells via interaction between 1) Fc region of the immunocytokine and the NK cell FcγR, and 2) IL-2 moiety of immunocytokine and the NK cell IL-2 receptor. Bound FcγRs and IL-2Rs transmit activation signals leading to enhanced NK cell function.
