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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Circulation. 2015 May 12;131(19):1691–1702. doi: 10.1161/CIRCULATIONAHA.114.006979

Figure 4.

Figure 4

Mitochondrial fragmentation in Pulmonary Arterial Hypertension (PAH). A. Mitochondria are more fragmented in PAH versus control pulmonary artery smooth muscle cells (PASMCs). Quantification of the mitochondrial fragmentation count reveals a doubling of the number of individual mitochondria in PAH versus control PASMCs. Scale bar = 20 μm. Reprinted with permission from 10. B. Increased mitochondrial fragmentation observed in PASMC of rats with PAH induced by exposure to chronic hypoxia plus the VEGF receptor antagonist, SU5416 (CH+SU 5416) or monocrotaline. Mitochondria were imaged by infection of cells with BacMam virus carrying a mitochondrial-targeted green fluorescent protein transgene. Reprinted with permission from 12.