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. Author manuscript; available in PMC: 2015 Nov 12.
Published in final edited form as: Nat Commun. 2015 May 12;6:7078. doi: 10.1038/ncomms8078

Figure 1. Acute deletion of liver insulin receptor leads to glucose intolerance and enhanced Foxo1 activity.

Figure 1

(A) Western blot of primary hepatocytes from mice treated with 10 nM insulin for 15 minutes and probed for specific proteins as indicated. AAVGFP=LWT mice, AAV-Cre=L-Insulin Receptor KO mice. (B,C) Blood glucose concentrations in mice after overnight fast (B) and overnight fasted following by 4 h refeeding of normal chow (C). NS:not significant * P<0.05. n=5 mice. (E) Intraperitoneal glucose tolerance test (2 g per kg) on overnight fasted mice. n=5 mice per group. * p<0.05 vs LWT (F) Insulin levels before and after 15 minutes following glucose injection IP. n=5 mice per group. *** p<0.001, ** p<0.01 vs LWT. All data are presented as mean ± s.e.m. Statistical analysis was performed using Students's t followed by two-tailed analysis. A P <0.05 was considered statistically significant.