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. 1992 Apr;89(4):1350–1353. doi: 10.1172/JCI115721

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

D T Hung 1, T K Vu 1, V I Wheaton 1, K Ishii 1, S R Coughlin 1
PMCID: PMC442997  PMID: 1313452

Abstract

Platelet activation by thrombin is critical for hemostasis and thrombosis. Structure-function studies with a recently cloned platelet thrombin receptor suggest that a hirudin-like domain in the receptor's extracellular amino terminal extension is a thrombin-binding determinant important for receptor activation. We now report that a peptide antiserum to this domain is a potent and specific antagonist of thrombin-induced platelet activation. This study demonstrates that the cloned platelet thrombin receptor is necessary for platelet activation by thrombin, and provides a strategy for developing blocking monoclonal antibodies of potential therapeutic value.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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