Table 4.
Location and accessory gene status of C. botulinum Group II neurotoxin gene clusters.
| Neurotoxin subtype | Representative strain | Neurotoxin cluster | Neurotoxin cluster location | Neurotoxin cluster locus | Accession number |
|---|---|---|---|---|---|
| B4 | Eklund 17B | ha | Plasmid | Plasmid-borne sitea | FR745876, CP001057 |
| E1 | Beluga | orf-X | Chromosome | rarA | ACSC000000001-16 |
| E1 | CB11/1-1 | orf-X | Plasmid | Plasmid-borne site | AORM01000001-171 |
| E3 | Alaska E43 | orf-X | Chromosome | rarA | CP001078 |
| E9 | CDC 66177 | orf-X | Chromosome | rarA | ALYJ01000001-119 |
| F6 | IFR 06/001 | orf-X | Chromosome | topB | KC516868b |
Strain Eklund 17B has been independently sequenced by two institutes; the two accession numbers are for both versions of the neurotoxin gene cluster-bearing plasmid.
Note: no genome sequence data are available for subtypes E2, E6, E7 and E8. Subtypes E4 and E5 are found exclusively in strains of neurotoxigenic C. butyricum.
a
The neurotoxin gene cluster-bearing plasmid of C. botulinum Group II type B4 does not display synteny with those of C. botulinum. Group I
b
Sequence of a 50 kb region of the chromosome containing the neurotoxin gene cluster.