Table 2. Risk of MACEs associated with NSAIDs in patients with AS stratified by frequency of exposure and types of NSAIDs adjust for Charlson comorbility index.

Total NSAIDs					COX-II					Non-selective NSAIDs
		OR	95%CI	P-value			OR	95%CI	P-value			OR	95%CI	P-value
3 months	Non-user	1	-	-	3 months	Non-user	1	-	-	3 months	Non-user	1	-	-
	<80%	1.21	0.87–1.70	0.259		<80%	0.56	0.26–1.25	0.1576		<80%	1.36	0.98–1.90	0.0669
	≥80%	0.78	0.37–1.67	0.5227		≥80%	0.38	0.07–2.18	0.275		≥80%	0.86	0.29–2.52	0.7801
6 months	Non-user	1	-	-	6 months	Non-user	1	-	-	6 months	Non-user	1	-	.
	<80%	1.13	0.79–1.61	0.5125		<80%	0.74	0.40–1.35	0.3218		<80%	1.2	0.85–1.69	0.29
	≥80%	0.81	0.38–1.76	0.5995		≥80%	0.15	0.02–1.45	0.1014		≥80%	1.21	0.44–3.31	0.7155
12 months	Non-user	1	-	-	12 months	Non-user	1	-	-	12 months	Non-user	1	-	-
	<80%	0.85	0.55–1.31	0.4572		<80%	0.61	0.37–1.02	0.0582		<80%	1.03	0.68–1.54	0.9023
	≥80%	0.48	0.19–1.22	0.1252		≥80%	0.43	0.06–3.15	0.4084		≥80%	0.61	0.17–2.20	0.4536
24 months	Non-user	1	-	-	24 months	Non-user	1	-	-	24 months	Non-user	1	-	-
	<80%	0.92	0.48–1.76	0.8022		<80%	0.68	0.44–1.05	0.0801		<80%	0.89	0.50–1.58	0.6893
	≥80%	0.5	0.16–1.56	0.2317		≥80%	1.41	0.08–24.67	0.8122		≥80%	0.7	0.13–3.70	0.6704
36 months	Non-user	1	-	-	36 months	Non-user	1	-	-	36 months	Non-user	1	-	-
	<80%	0.95	0.34–2.69	0.9292		<80%	0.78	0.52–1.15	0.2013		<80%	1.1	0.47–2.53	0.8309
	≥80%	0.52	0.13–2.10	0.3613		≥80%	1.43	0.08–25.09	0.8072		≥80%	1.38	0.23–8.45	0.7263

Abbreviation: NSAIDs, non-steroidal anti-inflammatory drugs; Total NSAID, include COX-II inhibitors and non-selective NSAIDs; COX-II, cyclooxygenase II inhibitors; MACEs, major adverse cardiac events