Table 3. Risk of stroke associated with NSAIDs in patients with AS stratified by frequency of exposure and types of NSAIDs adjust for Charlson comorbility index.

Total NSAIDs					COX-II					Non-selective NSAIDs
		OR	95%CI	P-value			OR	95%CI	P-value			OR	95%CI	P-value
3 months	Non-user	1	-	-	3 months	Non-user	1	-	-	3 months	Non-user	1	-	-
	<80%	1.35	0.93–1.95	0.1128		<80%	0.87	0.36–2.12	0.7655		<80%	1.44	1.00–2.07	0.0494
	≥80%	0.9	0.39–2.05	0.796		≥80%	0.38	0.07–2.15	0.2749		≥80%	0.6	0.16–2.22	0.447
6 months	Non-user	1	-	-	6 months	Non-user	1	-	-	6 months	Non-user	1	-	-
	<80%	1.2	0.82–1.77	0.351		<80%	0.99	0.51–1.93	0.9747		<80%	1.26	0.87–1.83	0.226
	≥80%	0.97	0.43–2.20	0.939		≥80%	0.18	0.02–1.85	0.1495		≥80%	1.76	0.54–5.73	0.3459
12 months	Non-user	1	-	-	12 months	Non-user	1	-	-	12 months	Non-user	1	-	-
	<80%	1	0.63–1.59	0.9999		<80%	0.84	0.49–1.45	0.5321		<80%	1.21	0.78–1.87	0.3959
	≥80%	0.61	0.23–1.63	0.3214		≥80%	0.29	0.04–1.84	0.1877		≥80%	1.27	0.29–5.65	0.752
24 months	Non-user	1	-	-	24 months	Non-user	1	-	-	24 months	Non-user	1	-	-
	<80%	1.04	0.51–2.10	0.9231		<80%	0.79	0.49–1.26	0.3158		<80%	1	0.54–1.86	0.9933
	> = 80%	0.72	0.22–2.36	0.5864		≥80%	0.36	0.03–3.75	0.3894		≥80%	1.07	0.19–6.16	0.9407
36 months	Non-user	1	-	-	36 months	Non-user	1	-	-	36 months	Non- user	1	-	-
	<80%	0.98	0.30–3.23	0.9755		<80%	0.97	0.63–1.49	0.8947		<80%	1.3	0.50–3.36	0.5905
	≥80%	0.55	0.12–2.60	0.4537		≥80%	0.14	0.09–24.53	0.7907		≥80%	1.36	0.21–8.97	0.7474

Abbreviation: NSAIDs, non-steroidal anti-inflammatory drugs; Total NSAID, include COX-II inhibitors and non-selective NSAIDs; COX-II, cyclooxygenase II inhibitors; MACEs, major adverse cardiac events