A) ETHIOPIA
|
N = 135
|
N = 450
|
|
Gender (female) |
93 |
(68.9%) |
280 |
(62.2%) |
0.16 |
Age at baseline, mean (SD) |
49.4 |
(13.4) |
50.6 |
(14.5) |
0.42 |
BMI at baseline, mean (SD) |
20.1 |
(2.4) |
20.0 |
(2.3) |
0.73 |
Scarring severity at baseline |
|
|
|
|
<0.0001 |
1a |
0 |
- |
1 |
(0.2%) |
|
1b |
6 |
(4.4%) |
4 |
(0.9%) |
|
1c |
20 |
(14.8%) |
21 |
(4.7%) |
|
2 |
107 |
(79.3%) |
342 |
(76.0%) |
|
3 |
2 |
(1.5%) |
82 |
(18.2%) |
|
Clinically inflamed (P2/P3) |
|
|
|
|
|
Baseline |
71 / 135 |
(52.6%) |
136 / 450 |
(30.2%) |
<0.0001 |
6-months |
26 / 95 |
(27.4%) |
50 / 341 |
(14.7%) |
0.0039 |
12-months |
58 / 130 |
(44.6%) |
84 / 430 |
(19.4%) |
<0.0001 |
18-months |
29 / 131 |
(22.1%) |
60 / 436 |
(13.8%) |
0.021 |
Clinically inflamed, 1+ episode |
97 |
(71.9%) |
192 |
(42.7%) |
<0.0001 |
Proportion of examinations with inflammation (%) |
|
|
|
<0.0001 |
0% |
38 |
(28.1%) |
258 |
(57.3%) |
|
25% |
28 |
(20.7%) |
77 |
(17.1%) |
|
33% |
11 |
(8.1%) |
25 |
(5.6%) |
|
50% |
19 |
(14.1%) |
32 |
(7.1%) |
|
66% |
9 |
(6.7%) |
16 |
(3.6%) |
|
75% |
11 |
(8.1%) |
18 |
(4.0%) |
|
100% |
19 |
(14.1%) |
24 |
(5.3%) |
|
B) TANZANIA
|
N = 173
|
N = 404
|
|
Gender (female) |
115 |
(66.5%) |
247 |
(61.1%) |
0.23 |
Age at baseline, mean (SD) |
50.9 |
(17.7) |
43.8 |
(16.9) |
<0.0001 |
BMI at baseline, mean (SD) |
21.6 |
(3.1) |
21.8 |
(2.9) |
0.47 |
Scarring severity at baseline |
|
|
|
|
<0.0001 |
1a |
45 |
(26.0%) |
170 |
(42.1%) |
|
1b |
63 |
(36.4%) |
170 |
(42.1%) |
|
1c |
45 |
(26.0%) |
47 |
(11.6%) |
|
2 |
14 |
(8.1%) |
12 |
(3.0%) |
|
3 |
6 |
(3.5%) |
5 |
(1.2%) |
|
Clinically inflamed (P2/P3) |
|
|
|
|
|
Baseline |
46 / 173 |
(26.6%) |
55 / 404 |
(13.6%) |
0.0002 |
6-months |
21 / 152 |
(13.8%) |
15 / 357 |
(14.7%) |
0.0001 |
12-months |
13 / 143 |
(9.1%) |
16 / 335 |
(4.8%) |
0.070 |
18-months |
6 / 135 |
(4.4%) |
3 / 325 |
(1.0%) |
0.013 |
Clinically inflamed, 1+ episode |
53 / 173 |
(30.6%) |
69 / 404 |
(17.1%) |
0.0003 |
Proportion of examinations with inflammation (%) |
|
|
|
0.0011 |
0% |
120 |
(69.4%) |
335 |
(82.9%) |
|
25% |
19 |
(11.0%) |
37 |
(9.2%) |
|
33% |
8 |
(4.6%) |
13 |
(3.2%) |
|
50% |
8 |
(4.6%) |
9 |
(2.2%) |
|
66% |
3 |
(1.7%) |
2 |
(0.5%) |
|
75% |
5 |
(2.9%) |
2 |
(0.5%) |
|
100% |
10 |
(5.8%) |
6 |
(1.5%) |
|