Table 1.

Pretreatment expression of specific biomarkers for xenografts that were sensitive versus resistant to cisplatin, cetuximab, and radiation treatments

Biomarker	Sensitive xenografts Average DAB MOD (95% CI)	Resistant xenografts Average DAB MOD (95% CI)	P-value
Cisplatin
ERCC1	0.085 (0.068, 0.101)	0.113 (0.097, 0.129)	0.020*
Cetuximab
EGFR	0.191 (0.164, 0.218)	0.114 (0.086, 0.141)	<0.001**
pEGFR	0.069 (0.052, 0.087)	0.071 (0.048, 0.094)	0.905
pAkt	0.010 (0.006, 0.013)	0.058 (0.037, 0.079)	<0.001**
pERK	0.023 (0.017, 0.029)	0.038 (0.020, 0.057)	0.093†
Radiation
EGFR	0.114 (0.086, 0.141)	0.191 (0.164, 0.218)	<0.001**
pEGFR	0.071 (0.048, 0.094)	0.069 (0.052, 0.087)	0.905
pAkt	0.058 (0.037, 0.079)	0.010 (0.006, 0.013)	<0.001**
pERK	0.038 (0.020, 0.057)	0.023 (0.017, 0.029)	0.093†
ERCC1	0.118 (0.102, 0.135)	0.084 (0.071, 0.097)	0.002**

DAB, 3,3′-diaminobenzidine; MOD, mean optical density.

^†P < 0.10, *P < 0.05, **P < 0.01.