Table 1.
Correlation between ANGPTL3 expression and clinical classification in OSCCs
| Clinical classification | Results of immunostaining no. patients (%) | |||
|---|---|---|---|---|
| Total | ANGPTL3 negative | ANGPTL3 positive | P value1 | |
| Age at surgery (years) | ||||
| <60 | 30 | 13 (43) | 17 (57) | 0.362 |
| ≥60, <70 | 26 | 13 (50) | 13 (50) | |
| ≥70 | 53 | 18 (32) | 35 (68) | |
| Gender | ||||
| Male | 74 | 31 (42) | 43 (58) | 0.683 |
| Female | 35 | 13 (36) | 22 (64) | |
| T-primary tumor | ||||
| T1 | 8 | 6 (75) | 2 (25) | 0.014 |
| T2 | 58 | 26 (44) | 32 (56) | |
| T3 | 20 | 6 (30) | 14 (70) | |
| T4 | 23 | 6 (26) | 17 (74) | |
| T1 + T2 | 66 | 32 (43) | 34 (57) | 0.033 |
| T3 + T4 | 43 | 12 (27) | 31 (73) | |
| N-regional lymph node | ||||
| N (−) | 63 | 26 (43) | 37 (58) | 0.823 |
| N (+) | 46 | 18 (39) | 28 (61) | |
| Stage | ||||
| I | 7 | 5 (71) | 2 (29) | 0.064 |
| II | 45 | 19 (43) | 26 (57) | |
| III | 18 | 9 (50) | 9 (50) | |
| IV | 39 | 11 (28) | 28 (72) | |
| Vascular invasion | ||||
| V(−) | 79 | 32 (40) | 47 (60) | 0.963 |
| V(+) | 30 | 12 (40) | 18 (60) | |
| Histopathologic type | ||||
| Well | 61 | 24 (38) | 37 (65) | 0.784 |
| Moderately | 42 | 17 (40) | 25 (60) | |
| Poorly | 6 | 3 (50) | 3 (50) | |
| Tumoral site | ||||
| Gingiva | 35 | 10 (34) | 25 (66) | 0.194 |
| Tongue | 61 | 29 (52) | 32 (48) | |
| Buccal mucosa | 7 | 3 (42) | 4 (58) | |
| Oral floor | 6 | 2 (33) | 4 (67) | |
| Total | 109 | 44 (40) | 65 (60) | |
1
P < 0.05 was considered significant.
2
χ2 test.
3
Fisher's exact test.
4
Mann–Whitney's U-test.