Table 1. List of parameters (ranges spanned for parameter space exploration of Fig 3 are indicated under squared brackets, N.A. stands for “Not Applicable”).

Parameter	Description	Value
Population 1 parameters
a	N.A.	1.0
b	N.A.	3.0
c	N.A.	1.0
d	N.A.	5.0
s1	N.A.	8.0
I1	Baseline input current	3.1
Global parameters
N	Number of neurons per population	40
x0	Degree of epileptogenicity	[-4.5, -2.5]
r	slow timescale constant	[0.000004, 0.00002]
Wmax	Maximum absolute amplitude of the white noise process W(t)	[1, 20]
Coupling parameters
CE	Normalized electrical coupling strength	[0, 1]
Gs i,i	intra-population synaptic coupling (μS)	[0, 0.4]
Gs i,j	inter-population synaptic coupling (i≠j) (μS)	[0, 0.4]
σ 1	Scaling factor for upscaled inputs towards P1	1/50
σ 2	Scaling factor for downscaled inputs towards P2	50
Tmax	Maximum concentration of transmitter in the synaptic cleft (mM)	1
αe	Forward binding rate constants of the excitatory synapses to open the receptors (mM-1 msec-1)	1.1
αi	Forward binding rate constants of the inhibitory synapses variable T to open the receptors (mM-1 msec-1)	5
βe	Backward binding rate constants of the excitatory synapses to close the receptors (msec-1)	0.19
βi	Backward binding rate constants of the inhibitory synapses to close the receptors (msec-1)	0.18
Vt	Value at which the transmitter release function is half-activated (mV)	2
Kp	Steepness of the transmitter release function exponential (mV)	5
Ee	Excitatory synapses reversal potential (mV)	0
Ei	Inhibitory synapses reversal potential (mV)	-80
Population 2 parameters
CM	Membrane capacitance (μF/cm2)	20.0
I2	Baseline input current (μA/cm2)	40.0
V1	Potential at which m ∞ = 0.5 (mV)	1.2
V2	Reciprocal of slope of voltage dependence of m ∞ (mV)	18.0
V3	Potential at which n ∞ = 0.5 (mV)	12.0
V4	Reciprocal of slope of voltage dependence of n ∞ (mV)	17.4
ϕ	Maximum rate constant for calcium channel opening (s-1)	0.067
ECa	Calcium ion channels reversal potential (mV)	120
EK	Potassium ion channels reversal potential (mV)	-84
EL	Leak current reference potential (mV)	-60