Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 4;68(7):453–462. doi: 10.1038/ja.2015.4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Japan Antibiotics Research Association

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

(a) Diagrammatic representation of target amino acids Leu19, Ala20 and Val23 in close proximity to the E. coli MscL channel gate, which were used for the de novo design of the designated ligands. (b) Docking energies (kcal mol⁻¹) of the ligands. (c) Iterative in silico docking of lead ligand 2, which gave rise to new class of antimicrobials including compounds 8–12. A full color version of this figure is available at The Journal of Antibiotics journal online.