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. 2015 Feb 4;68(7):453–462. doi: 10.1038/ja.2015.4

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Copyright © 2015 Japan Antibiotics Research Association

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Microscopic analysis of S. aureus ATCC 29213 treated with 10 at different concentrations. (a) SEM images and size measurements of S. aureus with an inset showing the mean±95% confidence (n=12). Scale bar 1 μm and magnification ~ × 85 000. (b) The change in the ‘a' parameter (representing bacteria curvature) is shown with representative 3D AFM images beneath (3 μm × 3 μm × 700 nm). The top 25 nm of an AFM scan was used as a basis for a parabolic equation fit y=ax²+bx+c to show the change in curvature after treatment with the drug. The inset shows the mean±95% confidence (n=10 for 1 × MBC and n=20 for other concentrations). A full color version of this figure is available at The Journal of Antibiotics journal online.