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Platelets were treated with nifedipine (5 μ M), or nifedipine combined with various drugs for 3 min, followed by addition of collagen for 6 min. The MMP-2 expression (A) and MMP-2 activity (B) were determined. Date were expressed as means ± SEM (n = 5). *** p < 0.001 compared with collagen alone group; ++ p < 0.01, +++ p < 0.001 compared with respective collagen+nifedipine-treated group.
