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. 2015 Feb 2;34(42):5341–5351. doi: 10.1038/onc.2014.450

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Combined in vivo activation of Gli2 and Pi3K/Akt signaling in murine B cells does not initiate a CLL-like phenotype. (a) Cre/loxP strategy for the combined activation of dominant active GLI2 and Pten-deletion-mediated Pi3k/Akt signaling in CD19+ B cells by the generation of CD19^cre/+;CLEG2;Pten^fl/fl (Pten^ΔB; ΔNGli2^Bact) mice. (b–e) Flow cytometry analysis of CD5⁺/CD19⁺ cells in PC (b), spleen (c), BM (d) and PB (e) of 8-month-old CD19^cre/+ control mice (ctrl), CD19^cre/+;Pten^fl/fl (Pten^ΔB) and CD19^cre/+;Pten^fl/fl;CLEG2 (Pten^ΔB; ΔNGli2^Bact) mice. B-cell-specific deletion of Pten increases CD5⁺/CD19⁺ cells in all organs analyzed. Simultaneous activation of Gli2 expression reverses this effect in BM and PB. Scatter dot plot with each dot representing an individual mouse. The mean value is indicated as bar, whiskers represent the s.e.m. ns: P>0.05; **P<0.01; ***P<0.001.