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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Biochem J. 2013 Dec 1;456(2):195–204. doi: 10.1042/BJ20130592

Figure 6. HEXIM1 inhibited hypoxia-induced invasion of MDA-MB-231 cells.

Figure 6

(A) MDA-MB-231 cells were transfected with expression vector for HEXIM1 or empty vector, in the absence or presence of increasing levels of expression vectors for HDAC1 or HIF-1α. Cells were then subjected to hypoxia treatment. Invasion of cells through Matrigel was assessed in the transwell invasion assay. *P < 0.05 compared with cells transfected with HEXIM1 expression vector only (i.e. 1:0). Panels are representative of five experiments. (B) Hypoxia-induced changes in HSulf-1 mRNA levels in control miRNA and HEXIM1 miRNA transfected MCF7 cells were quantified and normalized to GAPDH. Graphs are means±S.E.M. from three experiments. *P < 0.05 compared with control transfected cells with the same treatment.