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. 2014 Dec 22;34(39):5025–5036. doi: 10.1038/onc.2014.428

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Copyright © 2015 Macmillan Publishers Limited

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LARP1 correlates with clinical variables in cervical cancer. (a) Expression dataset comparing LARP1-mRNA levels in cervical squamous cell carcinoma (SCC) and non-cancer tissue. (b) Real-time PCR on RNA extracted from non-cancer cervical tissue (n=4) and cervical SCC (n=7). LARP1-mRNA levels relative to 18S ribosomal RNA (P=0.012, Student's t-test). (c) LARP1 immunostaining (brown) of normal cervical epithelium (N12), cervical intraepithelial neoplasia (CIN; N35) and invasive cervical SCC (N36), counterstained with haematoxylin. (d) LARP1 cytoplasmic scores for CIN compared to normal samples (P<0.0001) and in invasive cervical SCC compared to CIN samples (P<0.0001). (e) Expression dataset showing LARP1 expression in cervical SCC, stratified according to stage. *P⩽0.05, **P⩽ 0.001 and ***P⩽0.0001.