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. 2014 Dec 22;34(39):5025–5036. doi: 10.1038/onc.2014.428

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Depletion of LARP1 alters protein expression of interactome components, with wider effects on mTOR signaling pathway. (a) Level of LARP1 in HeLa cells transfected with control siRNA and two independent pooled siRNA sequences (siLARP1-1 and siLARP1-2). HSP60 was used as loading control. (b) Reverse-phase protein array after LARP1 knockdown (data normalized to control siRNA) shows altered expression of protein products of corresponding mRNAs identified as existing in complex with LARP1. (c) Change in protein expression and phosphorylation of mTOR signaling pathway components after LARP1 knockdown (data normalized to control siRNA). Experiments were performed ⩾3 times. Data are mean±s.e.m.