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. 2014 Dec 22;34(39):5025–5036. doi: 10.1038/onc.2014.428

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Copyright © 2015 Macmillan Publishers Limited

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LARP1 promotes tumor progression in vivo and is associated with increased mTOR expression in xenograft tumors. (a) Two million HeLa pTrex-LacZ or pTrex-LARP1 cells were injected subcutaneously into the posterior flank of non-obese diabetic-severe combined immunodeficiency mice and tumor volume was monitored by caliper measurements. Representative mice from each cohort are shown (scale bars, 1 cm). (b) Immunohistochemistry analysis of mTOR protein level in xenograft tumors (scale bars, 200 μm). (c) Relative quantification of mTOR protein levels in xenograft tumors generated from pTrex-LacZ and pTrex-LARP1 cells with a corresponding western blot shown (sequential numbers represent tumors from different mice). Data are means±s.e.m. *P⩽0.05.