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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Eur J Neurosci. 2011 Mar 17;33(8):1504–1518. doi: 10.1111/j.1460-9568.2011.07636.x

Fig. 5.

Fig. 5

Effects of GAT-1 or GAT-3 blockers on sIPSCs in rat GP neurons. (A) Sample traces showing sIPSCs recorded in the presence of 50 μm CNQX and 50 μm D-AP5, under control conditions (left) and during bath application of SKF 89976A (10 μm) (right). (B–D) The cumulative distribution of the amplitude, inter-event interval and half-decay time of sIPSCs obtained from the same GP neuron as in A. SKF 89976A significantly shifts the amplitude distribution curve (B) to the right and the inter-event interval distribution curve (C) to the left (P = 0.001), but has no significant effect on the distribution of sIPSC half-decay time (D, P = 0.7). (E) Amplitude distribution histograms of sIPSCs recorded before (left) and during (right) application of SKF 89976A. (F) Sample traces showing sIPSCs under control conditions (left) and in the presence of SNAP 5114 (10 μm) (right). (G–I) The cumulative distribution of the amplitude, inter-event interval and half-decay time of sIPSCs obtained from same neuron as in F. SNAP 5114 significantly shifts the amplitude distribution curve to the right (G) and inter-event interval distribution curve to the left (H) (P = 0.001), but has no significant effect on the distribution of sIPSC half-decay time (I) (P = 0.08). (J) Amplitude distribution histograms of sIPSCs recorded before (left) and during (right) application of SNAP 5114.