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PRMT5 methylation and regulation of the spliceosome. A cartoon representation of the function of PRMT5 methylation of splicing proteins in the cytoplasm. Methylated substrates are represented with a red “–CH3”. PRMT5, in complex with MEP50 and pICln, form the methylosome that targets spliceosomal subunits for methylation. pICln then chaperones the subunits to the SMN complex, resulting in proper targeting of RNAs to be spliced
