Fig. 7.

PRMT5 is altered in a range of cancers and its expression is correlated with poor prognosis. a The alteration frequency of prmt5 gene amplification, mutation, and deletions in a wide range of human cancers cataloged in The Cancer Genome Atlas (TCGA, accessed through the cBio Cancer Genomics Portal; http://www.cbioportal.org) was plotted in a histogram, ranging up to 4.5 % alteration in uterine cancer. This analysis did not include increased gene expression or protein abundance. b A Kaplan–Meier survival probability plot for high (orange) versus low (gray) prmt5 gene expression/mRNA level for lung cancer is shown, with high prmt5 expression resulting in a ~1.5-fold worse survival (hazard ratio) at very high significance. c A Kaplan–Meier survival probability plot for high (orange) versus low (gray) mep50 gene expression/mRNA level for lung cancer is shown, with high prmt5 expression resulting in a ~1.6-fold worse survival (hazard ratio) at very high significance. Survival data obtained from http://www.kmplot.com