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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pharmacol Biochem Behav. 2015 Apr 8;133:111–121. doi: 10.1016/j.pbb.2015.03.021

Figure 3.

Figure 3

Gonadal hormone modulation of acute THC-induced antinociception on the 50°C warm water tail withdrawal test (top panel) and the paw pressure test (bottom panel). Gonadectomized females (left panels) were treated with no hormone (GDX+0), estradiol (GDX+E2), progesterone (GDX+P4), or both ovarian hormones (GDX+E2/P4). Gonadectomized males (right panels) were treated with no hormone (GDX+0) or testosterone (GDX+T). Each point is the mean ± 1 SEM percent maximum possible effect (%MPE) of 21–24 rats. The 1.0 mg/kg dose is not shown for male groups (all points <20% MPE).