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Treatment groups.
| Capsule Implant | Hormone Injectiona | |
|---|---|---|
| FEMALES | ||
| Sham-GDX | Blank | Oil |
| GDX + 0 | Blank | Oil |
| GDX + E2 | Estradiol | Oil |
| GDX + P4 | Blank | Progesterone |
| GDX + E2/P4 | Estradiol | Progesterone |
| MALES | ||
| Sham-GDX | Blank | Oil |
| GDX + 0 | Blank | Oil |
| GDX + T | Testosterone | Oil |
oil or P4 was injected s.c. once every 5 days starting on the 4th day after the surgery day; THC dose-effect curves were obtained before and after chronic exposure to THC, starting approximately 4 hr after oil or P4 injection.
