Table 1.
Formulation | Deff (nm) | PDI | ζ-potential (mV) | LC (% w/w)b | |
---|---|---|---|---|---|
Dox | 17-AAG | ||||
Empty NG | 82 ± 1 | 0.18 | −45.0 ± 5.2 | - | - |
Dox/NG | 69 ± 2 | 0.20 | −19.1 ± 1.5 | 18.1 | - |
17-AAG/NG | 95 ± 1 | 0.17 | −25.7 ± 1.7 | - | 2.7 |
(Dox+17-AAG)/NG | 63 ± 5 | 0.16 | −21.5 ± 0.47 | 18.1 | 3.1 |
Effective diameter (Deff), polydispersity index (PDI) and ζ-potential were determined in water (pH 6.5).
Dox and 17-AAG content were determined by UV and HPLC, respectively. Loading capacity (LC) is expressed as mass of incorporated drug per mass of drug-loaded nanogels (w/w).