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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: J Control Release. 2015 Feb 3;208:59–66. doi: 10.1016/j.jconrel.2015.02.001

Table 1.

Physicochemical characterization of NGs before and after drug loadinga

Formulation Deff (nm) PDI ζ-potential (mV) LC (% w/w)b
Dox 17-AAG
Empty NG 82 ± 1 0.18 −45.0 ± 5.2 - -
Dox/NG 69 ± 2 0.20 −19.1 ± 1.5 18.1 -
17-AAG/NG 95 ± 1 0.17 −25.7 ± 1.7 - 2.7
(Dox+17-AAG)/NG 63 ± 5 0.16 −21.5 ± 0.47 18.1 3.1
a

Effective diameter (Deff), polydispersity index (PDI) and ζ-potential were determined in water (pH 6.5).

b

Dox and 17-AAG content were determined by UV and HPLC, respectively. Loading capacity (LC) is expressed as mass of incorporated drug per mass of drug-loaded nanogels (w/w).