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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: J Control Release. 2015 Mar 31;207:18–30. doi: 10.1016/j.jconrel.2015.03.033

Figure 5. Anti-inflammatory effects of exoCAT in PD mouse model.

Figure 5

The intranasal administration of exoCAT significantly decreased microglial activation (D, E) in 6-OHDA-intoxicated mice compared to those intoxicated with 6-OHDA and then treated with PBS (C). Catalase alone did not decrease inflammation in PD mice (F). Empty exosomes did not alter the microglial status in healthy animals (B) compared to healthy controls (A). The anti-inflammatory effects of the described exosomal formulations were quantified by the amount of activated microglial cells (G).