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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: J Control Release. 2015 Mar 31;207:18–30. doi: 10.1016/j.jconrel.2015.03.033

Figure 6. Neuroprotective effects of exoCAT in PD mouse model.

Figure 6

The i.n. administration of exoCAT protected DA neurons (D, E) in 6-OHDA-intoxicated mice compared to those intoxicated with 6-OHDA and then treated with PBS (C). Catalase alone was not efficient in this model (F). Empty exosomes did not affect the number of DA neurons in healthy animals (B) compared to healthy controls (A) indicating the absence of cytotoxic effects of the exosomal carriers. The neuroprotective effects of the described exosomal formulations were quantified by the amount of DA neurons in the SNpc (G).