Table 1.
Plasma creatinine and blood urea nitrogen (BUN) levels in Sprague-Dawley and bcrp−/− rats exposed to various doses of HgCl2.
| Strain | Dose | Creatinine (mg/dL) | BUN (mg/dL) |
|---|---|---|---|
| Sprague-Dawley | 0 | 0.34 ± 0.03 | 12.20 ± 0.4 |
| bcrp−/− | 0 | 0.32 ± 0.01 | 7.88 ± 0.1 |
| Sprague-Dawley | 0.5 μmol • kg−1 | 0.33 ± 0.01 | 12.91 ± 0.5 |
| bcrp−/− | 0.5 μmol • kg−1 | 0.40 ± 0.03 | 8.05 ± 0.1 |
| Sprague-Dawley | 1.5 μmol • kg−1 | 1.19 ± 0.64+ | 6.40 ± 1.4 |
| bcrp−/− | 1.5 μmol • kg−1 | 2.53 ± 0.97+ | 41.04 ± 1.5+* |
| Sprague-Dawley | 2.0 μmol • kg−1 | 2.05 ± 0.84+ | 24.08 ± 7.0+ |
| bcrp−/− | 2.0 μmol • kg−1 | 3.62 ± 0.8+* | 31.0 ± 5.4+* |
*
significantly different from corresponding Sprague-Dawley rats exposed to same dose;
+
significantly different from rats of same strain rats not exposed to HgCl2.