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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Invest Dermatol. 2015 Feb 10;135(6):1581–1589. doi: 10.1038/jid.2015.40

Figure 4. Pentobra is bactericidal in the sebaceous microcomedone environment.

Figure 4

Antimicrobial activity against P. acnes in the microcomedones was determined using a CFU assay. Pentobra, pen peptide or tobramycin (0 – 102 μM) were incubated for 3 hours in collected lipid-rich microcomedones isolated from four donors’ faces (A – D) using deep cleaning pore strips. Pentobra exhibits strong bactericidal activity while tobramycin and pen peptide did not. Data in A represent mean ±SD of three experiments using microcomedones extracted on different days from the same donor. Data in B, C, and D are each from a different donor.