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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Invest Dermatol. 2014 Nov 14;135(6):1540–1547. doi: 10.1038/jid.2014.485

Figure 5. Cx43 and paralogs.

Figure 5

Transmembrane domains are outlined; conserved residues are shaded gray. Disease-causing Cx43 mutations are shown above the alignment: EKVP reported here (red shade), ODDD (blue), ODDD with palmoplantar hyperkeratosis (purple), ODDD with Clouston syndrome (green shade); frameshifts (‘fs’), deletions (‘d’), insertions (‘i’). Mutation sites in paralogs reported to cause skin disease are in orange.