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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Eur J Pharm Biopharm. 2015 Mar 7;92:120–129. doi: 10.1016/j.ejpb.2015.02.017

Figure 5.

Figure 5

Hydrophilic and hydrophobic drug release profiles from gold nanoparticles coated with PC and TL (two layer), or PC, TL, and HDL (three layer). (A) Cisplatin-loaded two layer gold nanoparticles exhibited a burst during the first 5 hours, with ~35% of drug being released. A steady release followed over the next 14 days. (B) Cisplatin-loaded three layer gold nanoparticles also experienced an initial burst with ~70% of encapsulated drug being released within the first 5 hours. Drug release then became steady for the next 14 days. (C) Paclitaxel release from two layer gold nanoparticles was steady with only ~20% of encapsulated paclitaxel released during the 14 days. (D) Almost 100% of paclitaxel encapsulated within three layer gold nanoparticles was released by 14. Error bars represent standard deviation (n=3).