. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Eur J Pharm Biopharm. 2015 Mar 7;92:120–129. doi: 10.1016/j.ejpb.2015.02.017

Table 3.

Rate Constants and Correlation Coefficients Obtained from Modeling Drug Release from Two and Three Layer Gold Nanoparticles through the following: zero-order kinetic model, first-order kinetic model, simplified Higuchi model, and Korsmeyer-Peppas model.

Surface Modification	Incorporated Drug	Zero-Order		First-Order		Higuchi		Korsmeyer-Peppas
		k	r²	k	r²	k	r²	n	r²
TL-PC	Cisplatin	0.0725	0.8445	0.0008	0.5875	1.8554	0.8061	0.1248	0.9811
TL-PC-HDL	Cisplatin	11.699	0.7284	0.0890	0.8478	30.162	0.9287	0.2716	0.9897
TL-PC	Paclitaxel	0.0668	0.9127	0.0003	0.9313	1.294	0.9862	0.6787	0.9846
TL-PC-HDL	Paclitaxel	0.5589	0.9869	0.0037	0.9589	5.8756	0.8766	1.1348	0.9891