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. 2015 May 13;10(5):e0122754. doi: 10.1371/journal.pone.0122754

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© 2015 Lau et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — (A) Three-week pacing protocol. TSM/PPM = transmitter/ pacemaker, PES = programmed electrical stimulation. (B) TICM groups show dilated left ventricle and reduced ejection fraction. The red bars indicate end-systolic and end-diastolic LV internal dimensions (8 and 11 mm for LMC sham pacing and 12 and 15 mm for TICM). (C) Post-pacing protocol LV function presented as left ventricular ejection fraction in LMC-TICM, LQT1-TICM, and their sham controls. TICM rabbits show statistically significant differences in LV ejection fraction compared with sham; *P<0.05. (D) Quantification of I_Ks in LMC rabbits. Current amplitude was normalized to cell capacitance. Compared with LMC-SH-P (n = 12), significant downregulation of I_Ks was seen in LMC-TICM (n = 11).