Table 2. Sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy for the Alberta Infant Motor Scale and the Neuro-Sensory Motor Developmental Assessment at 4, 8 and 12 months for predicting motor impairment at 4 years.
| Age | Delayed on the predictor n (%) | Motor outcome at 4 years | Impaired on the outcome n (%) | Sensitivity (95%CI) | Specificity (95%CI) | +ve PV (95%CI) | -ve PV (95%CI) | LR+ (95% CI) | LR- (95% CI) | Accuracy (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Alberta Infant Motor Scale | ||||||||||
| 4 months | 19 (22%) | MABC<15th | 21 (26%) | 52 (30, 74) | 89 (78, 95) | 61 (36, 83) | 84 (73, 92) | 4.6 (2.0, 10.2) | 0.5 (0.3, 0.9) | 79 (69, 87) |
| MABC<5th | 18 (22%) | 61 (36, 83) | 89 (79, 95) | 61 (36, 83) | 89 (79, 95) | 5.6 (2.5, 12.3) | 0.4 (0.2, 0.8) | 83 (73, 90) | ||
| CP | 6 (7%) | 83 (36, 100) | 83 (73, 90) | 26 (9, 51) | 99 (92, 100) | 4.8 (2.7, 8.7) | 0.2 (0.0, 1.2) | 83 (73, 90) | ||
| 8 months | 23 (26%) | MABC<15th | 21 (26%) | 57 (34, 78) | 85 (74, 93) | 57 (34, 78) | 85 (74, 93) | 3.9 (1.9, 7.9) | 0.5 (0.3, 0.8) | 78 (68, 86) |
| MABC<5th | 18 (22%) | 61 (36, 83) | 84 (73, 92) | 52 (30, 74) | 89 (78, 95) | 3.9 (2.0, 7.7) | 0.5 (0.3, 0.8) | 79 (69, 87) | ||
| CP | 6 (7%) | 100 (54, 100) | 79 (69, 87) | 26 (10, 48) | 100 (94, 100) | 4.8 (3.1, 7.3) | * | 80 (71, 88) | ||
| 12 months | 31 (36%) | MABC<15th | 21 (26%) | 71 (48, 89) | 75 (63, 86) | 50 (31, 69) | 88 (77, 96) | 2.9 (1.7, 4.9) | 0.4 (0.2, 0.8) | 74 (64, 83) |
| MABC<5th | 18 (22%) | 78 (52, 94) | 75 (63, 85) | 47 (28, 66) | 92 (81, 98) | 3.1 (1.9, 5.1) | 0.3 (0.1, 0.7) | 76 (65, 84) | ||
| CP | 6 (7%) | 100 (54, 100) | 69 (58, 79) | 19 (7, 37) | 100 (94, 100) | 3.2 (2.3, 4.5) | * | 71 (61, 80) | ||
| Neuro-Sensory Motor Developmental Assessment | ||||||||||
| 4 months | 18 (21%) | MABC<15th | 21 (26%) | 38 (18, 62) | 85 (74, 93) | 47 (23, 72) | 80 (68, 89) | 2.6 (1.1, 5.8) | 0.7 (0.5, 1.0) | 73 (62, 82) |
| MABC<5th | 18 (22%) | 44 (22, 69) | 86 (75, 93) | 47 (23, 72) | 85 (74, 92) | 3.2 (1.4, 7.0) | 0.6 (0.4, 1.0) | 77 (66, 85) | ||
| CP | 6 (7%) | 83 (36, 100) | 84 (74, 91) | 28 (10, 53) | 99 (92, 100) | 5.2 (2.8, 9.6) | 0.2 (0.0, 1.2) | 84 (74, 91) | ||
| 8 months | 24 (28%) | MABC<15th | 21 (26%) | 52 (30, 74) | 82 (70, 91) | 50 (28, 72) | 83 (71, 92) | 2.9 (1.5, 5.7) | 0.6 (0.4, 0.9) | 74 (64, 83) |
| MABC<5th | 18 (22%) | 56 (31, 78) | 81 (70, 90) | 45 (24, 68) | 87 (75, 94) | 3.0 (1.5, 5.7) | 0.5 (0.3, 0.9) | 76 (65, 84) | ||
| CP | 6 (7%) | 100 (54, 100) | 78 (67, 86) | 25 (10, 47) | 100 (94, 100) | 4.5 (3.0, 6.8) | * | 79 (69, 87) | ||
| 12 months | 16 (18%) | MABC<15th | 21 (26%) | 38 (18, 62) | 90 (80, 96) | 57 (29, 82) | 81 (70, 89) | 3.9 (1.5, 9.9) | 0.7 (0.5, 1.0) | 77 (66, 85) |
| MABC<5th | 18 (22%) | 39 (17, 64) | 89 (79, 95) | 50 (23, 77) | 84 (73, 92) | 3.6 (1.4, 8.8) | 0.7 (0.5, 1.0) | 78 (68, 86) | ||
| CP | 6 (7%) | 100 (54, 100) | 88 (78, 94) | 38 (15, 65) | 100 (95, 100) | 8.1 (4.5, 14.5) | * | 89 (80, 94) | ||
| Age | Delayed on the predictor n (%) | Motor outcome at 4 years | Impaired on the outcome n (%) | Sensitivity (95%CI) | Specificity (95%CI) | +ve PV (95%CI) | -ve PV (95%CI) | +ve LR (95% CI) | -ve LR (95% CI) | Accuracy (95% CI) |
| Alberta Infant Motor Scale | ||||||||||
| 4 months | 19 (22%) | MABC<15th MABC<5th CP | 21 (26%) | 52 (30, 74) | 89 (78, 95) | 61 (36, 83) | 84 (73, 92) | 4.6 (2.0, 10.2) | 0.5 (0.3, 0.9) | 79 (69, 87) |
| 18 (22%) | 61 (36, 83) | 89 (79, 95) | 61 (36, 83) | 89 (79, 95) | 5.6 (2.5, 12.3) | 0.4 (0.2, 0.8) | 83 (73, 90) | |||
| 6 (7%) | 83 (36, 100) | 83 (73, 90) | 26 (9, 51) | 99 (92, 100) | 4.8 (2.7, 8.7) | 0.2 (0.0, 1.2) | 83 (73, 90) | |||
| 8 months | 23 (26%) | MABC<15th MABC<5th CP | 21 (26%) | 57 (34, 78) | 85 (74, 93) | 57 (34, 78) | 85 (74, 93) | 3.9 (1.9, 7.9) | 0.5 (0.3, 0.8) | 78 (68, 86) |
| 18 (22%) | 61 (36, 83) | 84 (73, 92) | 52 (30, 74) | 89 (78, 95) | 3.9 (2.0, 7.7) | 0.5 (0.3, 0.8) | 79 (69, 87) | |||
| 6 (7%) | 100 (54, 100) | 79 (69, 87) | 26 (10, 48) | 100 (94, 100) | 4.8 (3.1, 7.3) | * | 80 (71, 88) | |||
| 12 months | 31 (36%) | MABC<15th MABC<5th CP | 21 (26%) | 71 (48, 89) | 75 (63, 86) | 50 (31, 69) | 88 (77, 96) | 2.9 (1.7, 4.9) | 0.4 (0.2, 0.8) | 74 (64, 83) |
| 18 (22%) | 78 (52, 94) | 75 (63, 85) | 47 (28, 66) | 92 (81, 98) | 3.1 (1.9, 5.1) | 0.3 (0.1, 0.7) | 76 (65, 84) | |||
| 6 (7%) | 100 (54, 100) | 69 (58, 79) | 19 (7, 37) | 100 (94, 100) | 3.2 (2.3, 4.5) | * | 71 (61, 80) | |||
| Neuro-Sensory Motor Developmental Assessment | ||||||||||
| 4 months | 18 (21%) | MABC<15th MABC<5th CP | 21 (26%) | 38 (18, 62) | 85 (74, 93) | 47 (23, 72) | 80 (68, 89) | 2.6 (1.1, 5.8) | 0.7 (0.5, 1.0) | 73 (62, 82) |
| 18 (22%) | 44 (22, 69) | 86 (75, 93) | 47 (23, 72) | 85 (74, 92) | 3.2 (1.4, 7.0) | 0.6 (0.4, 1.0) | 77 (66, 85) | |||
| 6 (7%) | 83 (36, 100) | 84 (74, 91) | 28 (10, 53) | 99 (92, 100) | 5.2 (2.8, 9.6) | 0.2 (0.0, 1.2) | 84 (74, 91) | |||
| 8 months | 24 (28%) | MABC<15th MABC<5th CP | 21 (26%) | 52 (30, 74) | 82 (70, 91) | 50 (28, 72) | 83 (71, 92) | 2.9 (1.5, 5.7) | 0.6 (0.4, 0.9) | 74 (64, 83) |
| 18 (22%) | 56 (31, 78) | 81 (70, 90) | 45 (24, 68) | 87 (75, 94) | 3.0 (1.5, 5.7) | 0.5 (0.3, 0.9) | 76 (65, 84) | |||
| 6 (7%) | 100 (54, 100) | 78 (67, 86) | 25 (10, 47) | 100 (94, 100) | 4.5 (3.0, 6.8) | * | 79 (69, 87) | |||
| 12 months | 16 (18%) | MABC<15th MABC<5th CP | 21 (26%) | 38 (18, 62) | 90 (80, 96) | 57 (29, 82) | 81 (70, 89) | 3.9 (1.5, 9.9) | 0.7 (0.5, 1.0) | 77 (66, 85) |
| 18 (22%) | 39 (17, 64) | 89 (79, 95) | 50 (23, 77) | 84 (73, 92) | 3.6 (1.4, 8.8) | 0.7 (0.5, 1.0) | 78 (68, 86) | |||
| 6 (7%) | 100 (54, 100) | 88 (78, 94) | 38 (15, 65) | 100 (95, 100) | 8.1 (4.5, 14.5) | * | 89 (80, 94) | |||
Note-CI = Confidence Interval, CP = Cerebral Palsy, MABC = Movement Assessment Battery for Children-2nd edition; PV = Predictive Value; LR = Likelihood Ratio; Results are all percentages except for LR; Numbers in bold reflect the most accurate assessment for each outcomes
* Cannot calculate the LR- when the—ve PV is 100%