Fig 1. Morbidity observed in influenza virus infected and uninfected ferrets.
Six ferrets each were housed under the designated environmental conditions for the purpose of respiratory droplet transmission experimentation. Three ferrets each were presented with 103.8–105.5 pfu of PN99 or IN11 virus by aerosol inhalation and contact ferrets, n = 3, were placed in adjacent cages one day later. Inoculated animals, n = 3, were monitored for changes in minute volume by plethysmography (A) and weight (B) on the days noted. Endpoint (EP) data were collected on days 19–29 post inoculation. Both infected (C) and uninfected (D) contact animals were monitored for weight loss. Any contact animal shedding detectable virus in nasal washes and sero-converting to homologous virus was considered infected. EP data were collected on days 18–28 post contact. Mean values ± SEM is shown.