Table 1.
Circulating Maternal Metabolites (Amino Acids, Acylcarnitines, and FFAs) (Nanomoles per Milliliter) With the Highest Concentrations in Plasma and Those That Differed Significantly Among Treatment Groups
| Metabolites | C | T | T-Flutamide | T-Rosi | CV, % | P Adj |
|---|---|---|---|---|---|---|
| Amino acids | ||||||
| Glycine | 461.3 ± 28.6 | 498.2 ± 78.6 | 415.9 ± 47.6 | 453.7 ± 45.2 | 8.0 | NS |
| Valine | 175.3 ± 14.2 | 166.9 ± 8.2 | 187.8 ± 16.4 | 189.4 ± 11.9 | 4.5 | NS |
| Leucine | 152.3 ± 9.7 | 125.5 ± 7.9 | 151.3 ± 14.4 | 150.5 ± 12.74 | 5.7 | NS |
| Glutamic acid | 151.1 ± 10.5 | 124.9 ± 5.7 | 166.0 ± 8.9 | 169.1 ± 18.4 | 9.1 | NS |
| Alanine | 145.8 ± 21.3 | 144.3 ± 9.7 | 137.5 ± 17.4 | 141.5 ± 19.6 | 5.4 | NS |
| Acylcarnitines | ||||||
| L-carnitine | 11.559 ± 2.066 | 14.067 ± 1.655 | 16.844 ± 4.243 | 10.763 ± 1.305 | 8.6 | NS |
| Decenoyl (C10:1) | 1.756 ± 0.311 | 3.602 ± 0.815 | 2.267 ± 0.668 | 2.844 ± 0.630 | 1.8 | NS |
| Propionyl-(C3) | 0.592 ± 0.025 | 0.741 ± 0.060 | 0.595 ± 0.081 | 0.861 ± 0.104 | 1.7 | NS |
| 3-Hydroxydodecanoyl- (C12-OH) | 0.009 ± 0.001a | 0.004 ± 0.001b | 0.004 ± 0.001b | 0.007 ± 0.001a | 9.3 | <.01 |
| 3-Hydroxytetradecanoyl- (C14-OH) | 0.025 ± 0.005a | 0.010 ± 0.001b | 0.008 ± 0.001b | 0.018 ± 0.002a | 5.3 | <.05 |
| FFAs | ||||||
| Stearic acid (18:0) | 41.64 ± 4.11 | 40.99 ± 5.92 | 37.46 ± 3.52 | 35.51 ± 2.03 | 0.11 | NS |
| Oleic acid (18:1 [n-9]) | 31.16 ± 6.28 | 40.94 ± 4.39 | 41.70 ± 7.32 | 32.47 ± 2.36 | 0.37 | NS |
| Palmitic acid (16:0) | 15.75 ± 1.74 | 17.88 ± 2.19 | 19.43 ± 2.55 | 15.74 ± 1.09 | 1.09 | NS |
| Linoleic acid (18:2) | 2.69 ± 0.59 | 4.69 ± 1.09 | 5.67 ± 0.78 | 6.07 ± 1.83 | 0.57 | NS |
| α-Linolenic acid (18:3 [n-3]) | 0.10 ± 0.030a | 0.55 ± 0.17a | 0.92 ± 0.19b | 0.43 ± 0.12a | 0.43 | <.05 |
Abbreviations: Adj, adjusted; C, controls; CV, coefficient of variation; NS, not significant; T, treated with T; T-Flutamide, treated with T plus flutamide; T-Rosi, treated with T plus rosiglitazone. Values with different superscript letters (a, b) differ significantly (P < .05). NS values do not differ significantly (P > .05). All P values are shown as an adjusted P value (P adj). For a more complete list, see supplemental Tables 3–5.