Table 2.
Circulating Fetal Metabolites (Amino Acids, Acylcarnitines, and FFAs) (Nanomoles per Milliliter) With the Highest Concentrations in Plasma and Those That Differed Significantly Among Treatment Groups
| Metabolites | C | T | T-Flutamide | T-Rosi | CV, % | P Adj |
|---|---|---|---|---|---|---|
| Amino acids | ||||||
| Serine | 998.1 ± 65.8 | 834.8 ± 32.7 | 939.3 ± 101.9 | 1097.1 ± 80.9 | 9.0 | NS |
| Glycine | 587.4 ± 47.6 | 524.2 ± 25.3 | 523.0 ± 45.5 | 667.5 ± 65.0 | 8.0 | NS |
| Threonine | 389.7 ± 27.9 | 490.2 ± 35.7 | 410.0 ± 60.3 | 356.1 ± 40.1 | 7.0 | NS |
| Glutamine | 333.0 ± 39.7 | 289.7 ± 36.8 | 344.9 ± 37.3 | 273.4 ± 51.1 | 8.6 | NS |
| Valine | 293.0 ± 32.9 | 327.5 ± 25.8 | 316.9 ± 36.1 | 270.4 ± 17.6 | 4.5 | NS |
| Acylcarnitines | ||||||
| L-carnitine | 34.352 ± 6.124 | 34.663 ± 5.738 | 31.626 ± 3.818 | 41.486 ± 9.113 | 8.6 | NS |
| Decenoyl (C10:1) | 1.858 ± 0.505 | 3.397 ± 0.742 | 0.861 ± 0.227 | 2.057 ± 0.469 | 1.8 | NS |
| Propionyl-(C3) | 0.961 ± 0.093a | 0.905 ± 0.103a | 0.881 ± 0.169a | 1.850 ± 0.186b | 1.7 | <.05 |
| Butyryl-(C4) | 0.759 ± 0.038 | 0.835 ± 0424 | 0.822 ± 0.178 | 1.389 ± 0.236 | 1.3 | NS |
| Isovaleryl-(C5) | 0.199 ± 0.021 | 0.177 ± 0.017 | 0.169 ± 0.031 | 0.314 ± 0.055 | 1.2 | NS |
| FFAs | ||||||
| Stearic acid (18:0) | 3.78 ± 0.46 | 3.56 ± 0.27 | 3.42 ± 0.19 | 3.63 ± 0.18 | 0.11 | NS |
| Palmitic acid (16:0) | 2.99 ± 0.29 | 2.95 ± 0.14 | 3.51 ± 0.16 | 4.033 ± 0.38 | 1.09 | NS |
| Oleic acid (18:1 [n-9]) | 1.44 ± 0.34 | 2.37 ± 0.11 | 2.55 ± 0.18 | 2.57 ± 0.36 | 0.37 | NS |
| Linoleic acid (18:2) | 0.39 ± 0.16 | 0.14 ± 0.02 | 0.17 ± 0.01 | 0.15 ± 0.016 | 0.57 | NS |
| Vaccenic acid (18:1 [n-7]) | 0.37 ± 0.02 | 0.39 ± 0.02 | 0.37 ± 0.01 | 0.37 ± 0.05 | 1.24 | NS |
Abbreviations: Adj, adjusted; C, controls; CV, coefficient of variation; NS, not significant; T, treated with T; T-Flutamide, treated with T plus flutamide; T-Rosi, treated with T plus rosiglitazone. Values with different superscript letters (a, b) differ significantly (P < .05. NS values do not differ significantly (P > .05). All P values are shown as an adjusted P value (P adj). For a more complete list, see Supplemental Tables 6–8.