Table 4.
Correlation of Maternal Steroids With Fetal Metabolites
| Maternal | Fetal | C | T | T-Flutamide | T-Rosi | |
|---|---|---|---|---|---|---|
| FFAs (fetal) | P4 | Stearic acid (18:0) | −0.300 | 0.420a | −0.140 | −0.140 |
| Amino acids (fetal) | Estradiol | Phenylalanine | 0.350 | 0.940a | −0.030 | −0.290 |
| Estradiol | Tryptophan | 0.350 | 0.94a | 0.88a | −0.290 | |
| P4 | Aspargine | 1.000a | −0.370 | −0.030 | 0.420 | |
| Acylcarnitines (fetal) | Estradiol | Glutaryl-(C5-DC) | −0.181 | 0.559a | 0.539 | 0.304 |
| Estradiol | Octenoyl-(C8:1) | −0.726 | 0.250a | −0.226 | −0.761 | |
| Estradiol | Decenoyl-(C10:1) | −0.363 | −0.791a | −0.759b | 0.577 | |
| Estradiol | Tetradecenoyl-(C14:1) | −0.354 | −0.632a | −0.638 | −0.577 | |
| Estradiol | 3-Hydroxytetradecanoyl-(C14-OH) | −0.707 | −0.791a | −0.678 | −0.577 | |
| Estradiol | Hexadecanoyl-(C16) | −0.354 | −0.949a | −0.334 | −0.577 | |
| Estradiol | Octadecanoyl-(C18) | −0.354 | −0.949a | −0.516 | −0.577 | |
| Estradiol | Octadecenoyl-(C18:1) | 0.354 | −0.949a | −0.395 | −0.577 | |
| Estradiol | 3-Hydroxyoctadecadienoyl-(C18:2-OH) | −0.726 | −0.730a | −0.820 | −0.577 | |
| Estradiol | Arachidoyl-(C20) | −0.181 | −0.892a | −0.678 | −0.592 | |
| P4 | Propionyl-(C3) | 0.900a | −0.080 | −0.650 | −0.080 | |
| Testosterone | Dodecanoyl-(C12) | 0.700 | 0.540a | −0.820a | −0.080 |
Abbreviations: C, controls; P4, progesterone; T, treated with T; T-Flutamide, treated with T plus flutamide; T-Rosi, treated with T plus rosiglitazone.
a
A significant correlation between both metabolites within a treatment group.
b
A tendency (from P > .05 to P < .08) in the correlation between both metabolites within a treatment group.