Figure 2.
Adiponectin stimulates β-cell proliferation in PANIC-ATTAC mice. A and B, Representative immunofluorescence of phosphorylated Erk (pErk) (A) and Akt (pAkt) (B) in pancreatic islets of mice 2 weeks after initial dimerizer treatment. Upper panels, pErk or pAkt signal (red) only. Lower panels, Merged with insulin (green). C and D, Representative immunostaining (brown) of Nkx6.1 (C) and MafA (D) in pancreatic islets of mice 5 weeks after initial dimerizer treatment, counterstained with hematoxylin (blue).